LTE: Laboratory of Transcription and Epigenetics

Decoding the
Regulatory Syntax of
Gene Expression through
Innovative Molecular Technologies

We investigate the fundamental mechanisms of gene expression regulation through epigenetic control of transcription, advancing our understanding of how cells establish and maintain gene expression programs.

RESEARCH
OVERVIEW

The Laboratory of Transcription and Epigenetics (LTE) aims to uncover the mechanisms of gene expression control at the level of transcription, by which RNA molecules are transcribed from DNA.

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Epigenetic mechanisms of gene expression

1. Single-molecule fluorescence imaging-based studies of temporal dynamics of gene control

2. Elucidation of spatial chromatin interactions

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Development of epigenome editing-based novel therapeutics

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AI-based prediction of gene regulatory networks

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Epigenomic and transcriptomic pharmacology

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PUBLICATIONS

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Single-cell transcriptomic and pharmacological studies of onvansertib for small cell lung cancer treatment

H.D. Jeon*, I. Choi*. W. Song, J. Jung, J. Park, J-E. Kim, J.H. Lee, D.K. Yon, G.B. Lee, S.H. Ahn, H. Lee, I. Baek

Biomedicine & Pharmacotherapy (2025)

Gene expression inference based on graph neural networks using L1000 data

T.H. Kim*, H. Kim*. H. Hwang*, S. Kang*, K. Shin, I. Baek

Briefings in Bioinformatics (2025)

Single-molecule imaging for investigating the transcriptional control

I. Choi, I. Baek

Molecules and Cells (2025)

2026-1학기 연구실 회식

공도원 인턴의 장학금 선정을 축하합니다.

2025년 5월 연구실 회식

Science Communication

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SBS 교양이를 부탁해 (2025.07)
2025-07-01 Media

SBS 교양이를 부탁해 (2025.07)

백신에 대한 기술적인 설명

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TvN 너의 몸소리가 들려 (2025.06)
2025-06-01 Media

TvN 너의 몸소리가 들려 (2025.06)

오메가-3에 관한 과학 커뮤니케이션

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보다 BODA youtube (2025.04)
2025-04-01 Media

보다 BODA youtube (2025.04)

의약품에 관한 과학 커뮤니케이션

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FULL-TIME

2027년 입학 대학원생 (석사 및 석박통합과정) 모집

FULL-TIME

석사급 연구원 모집 (2026.04월 시작)